Product Overview
? 5-Amino-1MQ – Research-Grade NNMT Inhibitor for NAD⁺ Pathway Investigation
Synonyms: 5-Amino-1-methylquinolinium iodide, 5-Amino-1MQ
CAS Number: 42464-96-0
Chemical Formula: C₁₀H₁₁N₂⁺·I⁻
Molecular Weight: ~286.11 g/mol (iodide salt)
Form: Lyophilized powder
Purity: ≥98% (HPLC)
Use: For laboratory research only. Not for human or veterinary use.
? Overview
5-Amino-1MQ is a small-molecule compound used in laboratory research to study the inhibition of nicotinamide N-methyltransferase (NNMT), a cytosolic enzyme involved in methylation processes and NAD⁺ salvage pathways.
This molecule is under investigation in controlled environments for its role in modulating intracellular NAD⁺ levels, influencing cellular energy dynamics, and exploring metabolic reprogramming. Its compact structure and permeability profile make it suitable for in vitro and non-human model systems.
⚙️ Mechanistic Insights
Preclinical studies suggest 5-Amino-1MQ may act as a substrate-site NNMT inhibitor, with downstream effects observed in non-human models:
• NAD⁺ Modulation – May support NAD⁺ retention by limiting nicotinamide methylation
• SIRT1 Pathway Activation – Associated with mitochondrial activity and cellular stress responses
• AMPK Signalling – Studied for its role in metabolic regulation and energy expenditure
• Lipid Pathway Investigation – Linked to changes in adipocyte morphology and lipid turnover in animal systems
These findings are based on published scientific literature and are not indicative of human outcomes.
? Research Context
5-Amino-1MQ is being evaluated in laboratory environments for its relevance to:
• NNMT enzyme activity and NAD⁺ salvage pathway dynamics
• Redox balance in cell culture systems
• Adipocyte morphology and lipid metabolism
• Myocyte model investigation under metabolic stress
• NNMT expression analysis in non-human cell lines
All applications are strictly limited to research use and are not intended for therapeutic, diagnostic, or clinical purposes.
? Packaging & Storage
• Supplied as sterile-filtered lyophilized powder in sealed vials
• Store at –20°C, protected from light and moisture
• Reconstitute under sterile conditions using appropriate laboratory solvents
• Aliquot and refrigerate for multi-use stability
Note: Solvent compatibility and reconstitution protocols are available upon request for qualified research institutions
⚠️ Compliance Notice
This product is intended strictly for laboratory research use. It is not approved for human or veterinary applications and must not be used in food, drugs, or cosmetics. All information is based on published scientific literature and is provided for educational and informational purposes only. Researchers are responsible for ensuring compliance with local laws and institutional guidelines.