Product Overview
? AHK-Cu – Research-Grade Copper Tripeptide for Cellular & Matrix Investigation
Synonyms: Ala-His-Lys-Cu, Copper Tripeptide AHK
CAS Number: 767286-83-9
Sequence: Ala-His-Lys (complexed with Cu²⁺)
Molecular Weight: ~415.93 Da (copper-complexed form)
Form: Lyophilized powder or pre-formulated solution
Purity: ≥98% (HPLC)
Use: For laboratory research only. Not for human or veterinary use.
? Overview
AHK-Cu is a synthetic copper-binding tripeptide composed of alanine, histidine, and lysine, chelated with a divalent copper ion (Cu²⁺). Structurally related to GHK-Cu, AHK-Cu is under investigation in laboratory settings for its potential role in extracellular matrix remodelling, cellular signalling, and oxidative stress regulation.
Its compact structure and copper affinity support permeability and localized bioactivity in non-human model systems. AHK-Cu is being studied for its interactions with fibroblasts, endothelial cells, and dermal papilla cells in controlled environments.
⚙️ Mechanistic Insights
Preclinical studies suggest AHK-Cu may influence several biochemical pathways:
• VEGF Expression – May support angiogenic signalling and vascular integrity
• Fibroblast Activation – Associated with collagen and elastin synthesis via TGF-β and lysyl oxidase modulation
• Apoptosis Modulation – Studied for its impact on Bcl-2/Bax ratios and caspase activity in dermal cell models
• Oxidative Stress Response – Copper ion may stabilize superoxide dismutase (SOD), contributing to redox balance
• Androgen Pathway Investigation – Explored for its role in 5α-reductase and androgen receptor signalling in follicular systems
These findings are based on published preclinical data and are not indicative of human outcomes.
? Research Context
AHK-Cu is being evaluated in laboratory environments for its relevance to:
• Extracellular matrix remodelling and fibroblast proliferation
• Dermal papilla cell signalling and follicular biology
• Wound recovery and tissue adaptation
• Oxidative stress and redox balance
• Combinatorial studies with copper peptides and micro needling protocols
All applications are strictly limited to research use and are not intended for therapeutic, diagnostic, or clinical purposes.
? Packaging & Storage
• Supplied as sterile lyophilized powder or pre-formulated solution
• Store at –20°C, protected from light and moisture
• Reconstitute under sterile conditions
• Aliquot and refrigerate for multi-use stability
Note: Solvent compatibility and formulation protocols are available upon request for qualified research institutions
⚠️ Compliance Notice
This product is intended strictly for laboratory research use. It is not approved for human or veterinary applications and must not be used in food, drugs, or cosmetics. All information is based on published scientific literature and is provided for educational and informational purposes only. Researchers are responsible for ensuring compliance with local laws and institutional guidelines.
