Product Overview
ARA‑290 – Research‑Grade Peptide for Erythropoietin‑Derived, Inflammatory, and Neuromodulatory Pathway Investigation
Synonyms: Cibinetide; EPO‑Derived Helix‑B Peptide; Helix‑B Surface Peptide (HBSP)
CAS Number: 1202877‑80‑4
Sequence: Ala‑Glu‑Gly‑Val‑Leu‑Ser‑Glu‑Lys‑Ala‑Leu‑Leu‑Glu‑Leu‑Lys‑Gly‑Glu
Molecular Weight: Approx. 1,873 Da
Form: Lyophilised powder
Purity: ≥98% (HPLC)
Use: For laboratory research only. Not for human or veterinary use.
Overview
ARA‑290 (Cibinetide) is a synthetic 15‑amino‑acid peptide derived from the Helix‑B region of erythropoietin (EPO).
In research settings, it is widely used to investigate inflammatory modulation, neuroimmune signalling, and tissue‑protection pathways in controlled laboratory models.
Unlike full‑length EPO, ARA‑290 is engineered to selectively target the innate repair receptor (IRR) without engaging erythropoietic pathways, making it suitable for in vitro and non‑human in vivo studies examining cellular‑stress responses and neuroimmune communication.
Mechanistic Insights
Preclinical research has explored ARA‑290 in relation to several biological processes:
• Innate Repair Receptor (IRR) Activation – Studied for its selective interaction with the EPOR/CD131 heteroreceptor complex.
• Inflammatory‑Pathway Modulation – Investigated for its influence on cytokine‑related signalling in non‑human models.
• Neuroimmune Communication – Examined for its involvement in peripheral‑nerve and immune‑cell signalling pathways.
• Tissue‑Protection Mechanisms – Evaluated for its role in cellular‑stress responses and cytoprotective models.
These findings are based on published scientific literature and do not imply any therapeutic or physiological effects in humans.
Research Context
ARA‑290 is utilised exclusively within controlled laboratory environments for:
• Studies involving IRR‑mediated signalling and EPO‑derived peptide pathways
• Investigations into inflammatory and neuroimmune modulation
• Research on cellular‑stress responses and tissue‑protection models
• Comparative studies with erythropoietin analogues and other IRR‑targeting peptides
This material is not intended for therapeutic, diagnostic, or clinical use.
Packaging & Storage
• Supplied as a sterile‑filtered, lyophilised peptide
• Store at –20°C, protected from light and moisture
• Reconstitute under sterile laboratory conditions using bacteriostatic water or a suitable research‑grade diluent
• Store reconstituted solutions at 2–8°C and use according to institutional guidelines
Additional solubility and technical documentation are available to qualified research institutions upon request.
Compliance Notice
This product is intended solely for laboratory research purposes.
It is not approved for human or veterinary administration and must not be incorporated into food, cosmetics, pharmaceuticals, or any product intended for biological exposure.
All information provided is for scientific and educational reference only. Researchers are responsible for ensuring compliance with all applicable regulations, institutional policies, and safety standards.
