Product Overview
? CJC-1295 (No DAC) – Research-Grade GHRH Analog for Endocrine Axis Investigation
Synonyms: Modified GRF 1-29, CJC-1295 without DAC, Mod-GRF
CAS Number: 863288-34-0
Sequence: Tyr-D-Ala-Asp-Ala-Ile-Phe-Thr-Gln-Ser-Tyr-Arg-Lys-Val-Leu-Gly-Gln-Leu-Ser-Ala-Arg-Lys-Leu-Leu-Gln-Asp-Ile-Met-Ser-Arg-NH₂
Molecular Weight: ~3367.9 Da
Form: Lyophilized powder
Purity: ≥98% (HPLC)
Use: For laboratory research only. Not for human or veterinary use.
? Overview
CJC-1295 (No DAC) is a synthetic analog of growth hormone-releasing hormone (GHRH), modified to enhance receptor affinity and metabolic stability while preserving natural pulsatile GH release.
Unlike its DAC-bound counterpart, this version mimics endogenous GHRH kinetics and is suitable for short-acting, time-sensitive protocols. In laboratory settings, it is often studied in combination with growth hormone-releasing peptides (GHRPs) to evaluate pituitary response and endocrine modulation.
⚙️ Mechanistic Insights
Preclinical studies suggest CJC-1295 (No DAC) may influence several endocrine pathways:
• GHRH Receptor Activation – May support pulsatile GH secretion in alignment with circadian rhythm
• IGF-1 Pathway Engagement – Studied for hepatic stimulation and downstream signalling
• Protein and Lipid Metabolism – Explored in relation to anabolic and lipolytic markers
• Synergistic GH Release – Often paired with GHRPs (e.g., Ipamorelin) to assess combined pituitary output
Its short half-life (~30 minutes) allows for precise timing in acute endocrine studies.
? Research Context
CJC-1295 (No DAC) is being evaluated in controlled laboratory environments for its relevance to:
• Pituitary axis mapping and GH secretion studies
• Myocyte model systems and recovery protocols
• Lipid metabolism and body composition assays
• Sleep-phase and circadian rhythm investigations
• Combinatorial studies with GHRP-2, GHRP-6, or Ipamorelin
All applications are strictly limited to research use and are not intended for therapeutic, diagnostic, or clinical purposes.
? Packaging & Storage
• Supplied as sterile lyophilized powder
• Store at –20°C in a dry, light-protected environment
• Reconstitute under sterile conditions using bacteriostatic water or saline
• Avoid acidic solvents during reconstitution
• Refrigerate reconstituted solution at 2–8°C for multi-use stability
Note: Solvent compatibility and formulation protocols are available upon request for qualified research institutions
⚠️ Compliance Notice
This product is intended strictly for laboratory research use. It is not approved for human or veterinary applications and must not be used in food, drugs, or cosmetics. All information is based on published scientific literature and is provided for educational and informational purposes only. Researchers are responsible for ensuring compliance with local laws and institutional guidelines.
