Product Overview
? KPV – Research-Grade α-MSH Fragment for Inflammatory Pathway Investigation
Synonyms: Lys-Pro-Val, α-MSH(11–13) fragment
CAS Number: 820959-17-9
Sequence: Lys-Pro-Val
Molecular Weight: ~326.4 Da
Form: Lyophilized powder
Purity: ≥98% (HPLC)
Use: For laboratory research only. Not for human or veterinary use.
? Overview
KPV is a tripeptide fragment derived from the C-terminal region of alpha-melanocyte-stimulating hormone (α-MSH), studied for its anti-inflammatory and immunomodulatory properties. It is under investigation for its role in suppressing pro-inflammatory cytokines and modulating epithelial barrier integrity.
Its minimal structure and selective activity make it suitable for targeted studies in inflammation and immune response models.
⚙️ Mechanistic Insights
Preclinical studies suggest KPV may influence several biological pathways:
• NF-κB Inhibition – Studied for its role in downregulating inflammatory transcription factors
• Cytokine Suppression – Explored for effects on IL-1β, TNF-α, and IL-6 expression
• Barrier Function – Investigated for impact on epithelial integrity and mucosal resilience
• Melanocortin Pathway – May act via MC1R-independent mechanisms in localized inflammation
These findings are based on published scientific literature and are not indicative of human outcomes.
? Research Context
KPV is being evaluated in controlled laboratory environments for its relevance to:
• Inflammation-induced tissue damage and cytokine profiling
• Epithelial barrier function and mucosal immunity
• Autoimmune and allergic response models
• Combinatorial studies with oxidative stress or microbial challenge
All applications are strictly limited to research use and are not intended for therapeutic, diagnostic, or clinical purposes.
? Packaging & Storage
• Supplied as sterile-filtered lyophilized peptide
• Store at –20°C, protected from light and moisture
• Reconstitute under sterile conditions using bacteriostatic water or suitable diluent
• Refrigerate reconstituted solution at 2–8°C to preserve integrity
Note: Solvent compatibility and formulation protocols are available upon request for qualified research institutions.
⚠️ Compliance Notice
This product is intended strictly for laboratory research use. It is not approved for human or veterinary applications and must not be used in food, drugs, or cosmetics. All information is based on published scientific literature and is provided for educational and informational purposes only. Researchers are responsible for ensuring compliance with local laws and institutional guidelines.
