Product Overview
KPV – Research‑Grade α‑MSH Fragment for Inflammatory Pathway Investigation
Synonyms: Lys‑Pro‑Val; α‑MSH(11–13) fragment
CAS Number: 820959‑17‑9
Sequence: Lys‑Pro‑Val
Molecular Weight: Approx. 326.4 Da
Form: Lyophilised powder
Purity: ≥98% (HPLC)
Use: For laboratory research only. Not for human or veterinary use.
Overview
KPV is a tripeptide fragment derived from the C‑terminal region of alpha‑melanocyte‑stimulating hormone (α‑MSH). It is widely used in research examining inflammatory and immunomodulatory pathways.
Current investigations focus on its potential to influence pro‑inflammatory cytokine expression and support epithelial barrier integrity in controlled experimental systems.
Its compact structure and selective activity make it suitable for targeted studies involving inflammation, mucosal biology, and immune‑response regulation.
Mechanistic Insights
Preclinical research has explored KPV in relation to several biological mechanisms:
• NF‑κB Pathway Modulation – Studied for its potential to downregulate inflammatory transcription factors.
• Cytokine Expression – Investigated for its effects on IL‑1β, TNF‑α, and IL‑6 in non‑human models.
• Barrier Integrity – Examined for its influence on epithelial resilience and mucosal defence.
• Melanocortin‑Related Activity – Evaluated for actions that may occur independently of MC1R signalling in localised inflammation.
These findings are derived from published scientific literature and do not imply any clinical or physiological effects in humans.
Research Context
KPV is utilised exclusively within controlled laboratory environments for:
• Studies involving inflammation‑induced tissue responses and cytokine profiling
• Investigations into epithelial barrier function and mucosal immunity
• Experimental autoimmune or allergic response models
• Research combining oxidative stress, microbial challenge, or epithelial injury paradigms
This material is not intended for therapeutic, diagnostic, or clinical use.
Packaging & Storage
• Supplied as a sterile‑filtered, lyophilised peptide
• Store at –20°C, protected from moisture and light
• Reconstitute under sterile laboratory conditions using bacteriostatic water or a suitable research‑grade diluent
• Store reconstituted solutions at 2–8°C and use according to institutional guidelines
Additional solubility and formulation data are available to qualified research institutions upon request.
Compliance Notice
This product is intended solely for laboratory research purposes.
It is not approved for human or veterinary administration and must not be incorporated into food, cosmetics, pharmaceuticals, or any product intended for biological exposure.
All information provided is for scientific and educational reference only. Researchers are responsible for ensuring compliance with all applicable regulations, institutional policies, and safety standards.
