Product Overview
Melanotan 1 – Research‑Grade α‑MSH Analogue for Melanocortin and Pigmentation Pathway Investigation
Synonyms: Afamelanotide; α‑MSH analogue
CAS Number: 75921‑69‑6
Sequence: Ac‑Ser‑Tyr‑Ser‑Nle‑Glu‑His‑D‑Phe‑Arg‑Trp‑Gly‑Lys‑Pro‑Val‑NH₂
Molecular Weight: Approx. 1,645 Da
Form: Lyophilised powder
Purity: ≥98% (HPLC)
Use: For laboratory research only. Not for human or veterinary use.
Overview
Melanotan 1 (Afamelanotide) is a synthetic analogue of alpha‑melanocyte‑stimulating hormone (α‑MSH), designed to investigate melanocortin receptor signalling and pigmentation‑related biochemical pathways.
In research settings, it is widely used to study MC1R‑mediated processes, melanogenesis, and cellular responses to ultraviolet‑related stress in controlled laboratory models.
Its structural stability and receptor selectivity make it suitable for in vitro and non‑human in vivo studies examining pigmentation biology and melanocortin‑driven cellular mechanisms.
Mechanistic Insights
Preclinical research has explored Melanotan 1 in relation to several biological processes:
• MC1R Activation – Studied for its selective agonist activity at the melanocortin‑1 receptor.
• Melanogenesis Pathways – Investigated for its involvement in melanin synthesis and pigment‑cell signalling.
• Cellular Stress Responses – Examined for its influence on oxidative and UV‑related stress pathways in non‑human models.
• Melanocortin System Modulation – Evaluated for its structure–activity relationship within the broader melanocortin receptor family.
These findings are based on published scientific literature and do not imply any therapeutic or physiological effects in humans.
Research Context
Melanotan 1 is utilised exclusively within controlled laboratory environments for:
• Studies involving melanocortin receptor signalling
• Investigations into pigmentation biology and melanogenesis
• Research on UV‑response pathways and oxidative‑stress models
• Comparative studies with α‑MSH, Melanotan II, and other melanocortin analogues
This material is not intended for therapeutic, diagnostic, or clinical use.
Packaging & Storage
• Supplied as a sterile‑filtered, lyophilised peptide
• Store at –20°C, protected from light and moisture
• Reconstitute under sterile laboratory conditions using bacteriostatic water or a suitable research‑grade diluent
• Store reconstituted solutions at 2–8°C and use according to institutional guidelines
Additional solubility and technical documentation are available to qualified research institutions upon request.
Compliance Notice
This product is intended solely for laboratory research purposes.
It is not approved for human or veterinary administration and must not be incorporated into food, cosmetics, pharmaceuticals, or any product intended for biological exposure.
All information provided is for scientific and educational reference only. Researchers are responsible for ensuring compliance with all applicable regulations, institutional policies, and safety standards.
