Product Overview
? Melanotan 1 – Research-Grade MC1R Agonist for Pigmentation Pathway Investigation
Synonyms: Afamelanotide, [Nle⁴, D-Phe⁷]-α-MSH, CUV1647
CAS Number: 75921-69-6
Sequence: Ac-Ser-Tyr-Ser-Nle⁴-Glu-His-D-Phe⁷-Arg-Trp-Gly-Lys-Pro-Val-NH₂
Molecular Weight: ~1646.9 Da
Form: Lyophilized powder
Purity: ≥98% (HPLC)
Use: For laboratory research only. Not for human or veterinary use.
? Overview
Melanotan 1 is a synthetic peptide analog of alpha-melanocyte-stimulating hormone (α-MSH), designed to selectively activate the melanocortin 1 receptor (MC1R). This receptor is primarily expressed in melanocytes and is involved in regulating melanin synthesis and UV response.
In laboratory settings, Melanotan 1 is under investigation for its role in pigmentation signaling, melanocyte activation, and photoprotective mechanisms. Its linear structure and receptor specificity make it suitable for targeted studies in non-human models.
⚙️ Mechanistic Insights
Preclinical studies suggest Melanotan 1 may influence several biological pathways:
• MC1R Activation – May initiate cAMP-mediated signaling cascades that support melanogenesis
• Tyrosinase Modulation – Studied for its role in upregulating melanin-producing enzymes
• UV Response – Explored for its impact on pigmentation density and cellular resilience
• Receptor Selectivity – Exhibits minimal activity at MC3R and MC4R, reducing systemic effects in research models
These findings are based on published scientific literature and are not indicative of human outcomes.
? Research Context
Melanotan 1 is being evaluated in controlled laboratory environments for its relevance to:
• Melanocyte biology and pigmentation signaling
• UV-induced cellular response and photoprotection
• Eumelanin vs pheomelanin expression ratios
• Combinatorial studies with UVB exposure in pigmentation assays
All applications are strictly limited to research use and are not intended for therapeutic, diagnostic, or clinical purposes.
? Packaging & Storage
• Supplied as sterile-filtered lyophilized peptide
• Store at –20°C, protected from light and moisture
• Reconstitute under sterile conditions using bacteriostatic water, acetic acid, or suitable diluent
• Refrigerate reconstituted solution at 2–8°C to preserve integrity
Note: Solvent compatibility and formulation protocols are available upon request for qualified research institutions
⚠️ Compliance Notice
This product is intended strictly for laboratory research use. It is not approved for human or veterinary applications and must not be used in food, drugs, or cosmetics. All information is based on published scientific literature and is provided for educational and informational purposes only. Researchers are responsible for ensuring compliance with local laws and institutional guidelines.
