Product Overview
PT‑141 – Research‑Grade Melanocortin Receptor Agonist for Neuroendocrine Pathway Investigation
Synonyms: Bremelanotide; Melanotan II derivative
CAS Number: 189691‑06‑3
Sequence: Ac‑Nle‑Asp‑His‑D‑Phe‑Arg‑Trp‑Lys‑OH
Molecular Weight: Approx. 1,024 Da
Form: Lyophilised powder
Purity: ≥98% (HPLC)
Use: For laboratory research only. Not for human or veterinary use.
Overview
PT‑141 (Bremelanotide) is a synthetic heptapeptide derived from the melanocortin analogue Melanotan II. It is widely used in research examining melanocortin receptor signalling, neuroendocrine pathways, and central regulatory mechanisms.
Scientific investigations focus on its activity at MC3R and MC4R receptors, which are associated with neurochemical modulation, autonomic signalling, and behavioural pathways in controlled laboratory models.
Its stability and receptor‑selective profile make it suitable for in vitro and non‑human in vivo studies exploring melanocortin‑related neurobiology.
Mechanistic Insights
Preclinical research has explored PT‑141 in relation to several neurobiological processes:
• Melanocortin Receptor Activation – Studied for its agonist activity at MC3R and MC4R receptors.
• Central Nervous System Signalling – Investigated for its involvement in hypothalamic and autonomic pathways.
• Neuroendocrine Modulation – Examined for its influence on central regulatory circuits in non‑human models.
• Peptide–Receptor Interactions – Evaluated for its structure–activity relationship within the melanocortin system.
These findings are based on published scientific literature and do not imply any therapeutic or physiological effects in humans.
Research Context
PT‑141 is utilised exclusively within controlled laboratory environments for:
• Studies involving melanocortin receptor signalling
• Investigations into neuroendocrine and autonomic pathways
• Research on central regulatory mechanisms and peptide–receptor interactions
• Comparative studies with Melanotan II and other melanocortin analogues
This material is not intended for therapeutic, diagnostic, or clinical use.
Packaging & Storage
• Supplied as a sterile‑filtered, lyophilised peptide
• Store at –20°C, protected from light and moisture
• Reconstitute under sterile laboratory conditions using bacteriostatic water or a suitable research‑grade diluent
• Store reconstituted solutions at 2–8°C and use according to institutional guidelines
Additional solubility and technical documentation are available to qualified research institutions upon request.
Compliance Notice
This product is intended solely for laboratory research purposes.
It is not approved for human or veterinary administration and must not be incorporated into food, cosmetics, pharmaceuticals, or any product intended for biological exposure.
All information provided is for scientific and educational reference only. Researchers are responsible for ensuring compliance with all applicable regulations, institutional policies, and safety standards.
