Product Overview
? PT-141 – Research-Grade Melanocortin Agonist for Neuroendocrine Pathway Investigation
Synonyms: Bremelanotide, Vyleesi, α-MSH Analog
CAS Number: 189691-06-3
Sequence: Ac-Nle-cyclo[Asp-His-D-Phe-Arg-Trp-Lys]-OH
Molecular Weight: ~1025.2 Da
Form: Lyophilized powder or sterile solution
Purity: ≥98% (HPLC)
Use: For laboratory research only. Not for human or veterinary use.
? Overview
PT-141 is a synthetic peptide analog derived from Melanotan II, designed to selectively activate melanocortin receptors MC3R and MC4R in the central nervous system. It is under investigation in laboratory settings for its role in neuroendocrine signalling, behavioural modulation, and melanocortin pathway mapping.
Unlike peripheral agents that target vascular mechanisms, PT-141 is studied for its central activity, making it a unique scaffold for research into hypothalamic signalling and receptor-specific modulation.
⚙️ Mechanistic Insights
Preclinical studies suggest PT-141 may influence several biological pathways:
• MC4R Activation – May initiate central signalling cascades associated with behavioural and autonomic responses
• Dopaminergic Modulation – Studied for its role in hypothalamic neurotransmitter release
• Neurogenic Vasodilation – Explored in relation to autonomic regulation of blood flow
• Appetite Signalling – Investigated for its interaction with melanocortin pathways involved in energy balance
These findings are based on published scientific literature and are not indicative of human outcomes.
? Research Context
PT-141 is being evaluated in controlled laboratory environments for its relevance to:
• Central melanocortin receptor mapping
• Neuroendocrine signalling and behavioural response models
• Appetite regulation and energy homeostasis
• Dopamine pathway analysis in non-human systems
• Combinatorial protocols with GHRH analogs or amylin derivatives
All applications are strictly limited to research use and are not intended for therapeutic, diagnostic, or clinical purposes.
? Packaging & Storage
• Supplied as sterile-filtered lyophilized powder
• Store at –20°C in a dry, light-protected environment
• Reconstitute under sterile conditions using bacteriostatic water or saline
• Avoid acidic solvents during reconstitution
• Refrigerate reconstituted solution at 2–8°C to preserve integrity
Note: Solvent compatibility and formulation protocols are available upon request for qualified research institutions
⚠️ Compliance Notice
This product is intended strictly for laboratory research use. It is not approved for human or veterinary applications and must not be used in food, drugs, or cosmetics. All information is based on published scientific literature and is provided for educational and informational purposes only. Researchers are responsible for ensuring compliance with local laws and institutional guidelines.
