Product Overview
? Retatrutide – Research-Grade Tri-Agonist Peptide for Metabolic Pathway Investigation
Synonyms: LY3437943
CAS Number: 2768074-01-5
Sequence: C₂₈₄H₄₅₂N₇₈O₈₅
Molecular Weight: ~6,000 Da (approximate)
Form: Lyophilized powder
Purity: ≥98% (HPLC)
Use: For laboratory research only. Not for human or veterinary use.
? Overview
Retatrutide is a synthetic investigational peptide designed to act as a triple receptor agonist, engaging GLP-1R (glucagon-like peptide-1 receptor), GIPR (glucose-dependent insulinotropic polypeptide receptor), and GCGR (glucagon receptor).
In laboratory settings, Retatrutide is being studied for its role in energy balance, endocrine signalling, and metabolic regulation. Its multi-receptor profile makes it a candidate for exploring coordinated hormonal pathways in non-human models.
⚙️ Mechanistic Insights
Preclinical research suggests Retatrutide may influence several biological pathways:
• GLP-1R Activation – May support insulin secretion and delay gastric emptying
• GIPR Activation – Studied for its role in lipid metabolism and insulinotropic signalling
• GCGR Activation – Explored for its impact on energy expenditure via hepatic and adipose tissue pathways
This tri-agonist profile is being evaluated for its ability to modulate caloric intake, thermogenesis, and insulin sensitivity in controlled research environments.
? Research Context
Retatrutide is being evaluated in laboratory environments for its relevance to:
• Adiposity and body weight modulation
• Glucose tolerance and insulin dynamics
• Lipid metabolism and hepatic fat content
• Multi-axis incretin and glucagon signalling
All applications are strictly limited to research use and are not intended for therapeutic, diagnostic, or clinical purposes.
? Packaging & Storage
• Supplied as sterile-filtered lyophilized peptide
• Store at –20°C in a dry, desiccated environment
• Reconstitute under sterile conditions using bacteriostatic water, acetic acid, or suitable diluent
• Refrigerate reconstituted solution at 2–8°C to preserve integrity
Note: Solvent compatibility and formulation protocols are available upon request for qualified research institutions
⚠️ Compliance Notice
This product is intended strictly for laboratory research use. It is not approved for human or veterinary applications and must not be used in food, drugs, or cosmetics. All information is based on published scientific literature and is provided for educational and informational purposes only. Researchers are responsible for ensuring compliance with local laws and institutional guidelines.
