Product Overview
TB‑500 – Research‑Grade Thymosin Beta‑4 Fragment for Cytoskeletal and Tissue‑Repair Pathway Investigation
Synonyms: Thymosin Beta‑4 Fragment; TB500
CAS Number: 77591‑33‑4 (CAS commonly associated with Thymosin Beta‑4; TB‑500 is a synthetic research fragment)
Sequence: Ac‑Ser‑Asp‑Lys‑Pro‑Ala‑Asp‑Glu‑Ile‑Glu‑Lys‑Phe‑Asp‑Lys‑Ser‑Lys‑Leu‑Lys‑Lys‑Thr‑Glu‑Thr‑Gln‑Glu‑Lys‑Gln‑Ala‑Gly‑Glu‑Ser
Molecular Weight: Approx. 3,120 Da
Form: Lyophilised powder
Purity: ≥98% (HPLC)
Use: For laboratory research only. Not for human or veterinary use.
Overview
TB‑500 is a synthetic research peptide modelled on a functional region of Thymosin Beta‑4 (Tβ4), a naturally occurring actin‑binding protein involved in cytoskeletal organisation.
It is widely used in laboratory studies investigating cell migration, angiogenesis, and tissue‑repair‑related biochemical pathways.
Its stability and selective activity make it suitable for in vitro and non‑human in vivo models examining wound‑healing mechanisms, cellular motility, and cytoskeletal regulation.
Mechanistic Insights
Preclinical research has explored TB‑500 in relation to several biological processes:
• Actin‑Binding Pathways – Studied for its potential to influence actin polymerisation and cytoskeletal dynamics.
• Cell Migration – Investigated for its involvement in promoting motility in various cell types in controlled laboratory settings.
• Angiogenesis – Examined for its effects on endothelial cell behaviour and vascular‑growth models.
• Tissue‑Repair Signalling – Evaluated for its role in pathways associated with regeneration and extracellular‑matrix remodelling.
These findings are based on published scientific literature and do not imply any therapeutic or physiological effects in humans.
Research Context
TB‑500 is utilised exclusively within controlled laboratory environments for:
• Studies involving cytoskeletal organisation and actin‑binding proteins
• Investigations into wound‑healing and tissue‑repair pathways
• Angiogenesis and endothelial‑cell behaviour models
• Comparative research with full‑length Thymosin Beta‑4 or related peptides
This material is not intended for therapeutic, diagnostic, or clinical use.
Packaging & Storage
• Supplied as a sterile‑filtered, lyophilised peptide
• Store at –20°C, protected from light and moisture
• Reconstitute under sterile laboratory conditions using bacteriostatic water or a suitable research‑grade diluent
• Store reconstituted solutions at 2–8°C and use according to institutional guidelines
Additional solubility and technical documentation are available to qualified research institutions upon request.
Compliance Notice
This product is intended solely for laboratory research purposes.
It is not approved for human or veterinary administration and must not be incorporated into food, cosmetics, pharmaceuticals, or any product intended for biological exposure.
All information provided is for scientific and educational reference only. Researchers are responsible for ensuring compliance with all applicable regulations, institutional policies, and safety standards.
